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Running back Jace Clarizio flipped his commitment from his local team, Michigan State, to Alabama. The decision, announced by Clarizio on social media Tuesday, comes after the East Lansing (Mich.) High standout visited head coach Kalen DeBoer's Crimson Tide on Nov. 16. "Great program," Clarizio told On3. "Playing on the biggest level. ... All the people and coaches I met and interacted with were all great people. The atmosphere was crazy." The 5-foot-11, 195-pounder is ranked as the No. 33 running back by On3 and tabbed No. 35 in their industry ranking. In May, he had verbally committed to the Spartans, where his father, Craig Johnson, was a running back and defensive back who was a member of the 1987 Rose Bowl-winning squad under coach George Perles. --Field Level Media

The NFL suspended Tennessee Titans safety Julius Wood six games on Tuesday for violating the policy on performing-enhancing substances. There are five games remaining this season for the Titans (3-9), so Wood's suspension will bleed into Week 1 of 2025. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. Stacker analyzed data from the National Retail Federation, NielsenIQ, and other sources to see how gifting is becoming greener this holiday season. Click for more. How to shop greener for the holidays. Tips for eco-conscious gifters of all levels.Sir Keir Starmer was speaking at the Joint Expeditionary Force (JEF) conference in Estonia where he met leaders of other Baltic states. After signing an energy partnership with Norwegian Prime Minister Jonas Gahr Store in Bergen, Sir Keir flew to Estonia where he spoke alongside Mr Store and their Estonian counterpart Kristen Michal. Asked what else could be done to support Ukraine, Sir Keir said: “There is an ever-increasing demand for more capability. That is understandable, and Ukraine needs all the capability that it can get, so I think all of us have put in more capability into Ukraine by way of equipment.” He added: “A lot of money has been raised, funding has been raised, but more is going to be needed.” The Prime Minister’s also discussed making the economic case at home for continued support for Ukraine. Sir Keir said: “Making the case on the significance of Ukraine, making the case, to double down, linking it back to each of our countries – what does it mean for us if Russia succeeds, is a really important question that we have to answer with our people to make it clear why it is that we are so supportive of Ukraine, why it is that we must stand with our allies on this, why it is we must make sure that Nato is put in the strongest position as well. “Now, this is a different world to the world of 10, 20 years ago, to recognise the world that we are living in, there’s a positive case as well to be made. “Defence spending doesn’t sort of sit in a silo over here with no effect on the rest of the economy, no effect on technology. “It has a huge effect on technologies, the cutting edge of technology and change which can then be used in other areas. “It binds countries together. I think all of us have got joint projects on in terms of defence capabilities that bind us together. There’s a huge number of well-paid jobs that are very important to our economy in defence spending as well. “But we have to make that positive case. I don’t personally feel that we can sort of sit back and assume that all of those in our respective countries necessarily accept all of our arguments unless we make them in that positive way, which I do think the argument can and should and must be made. “But the challenge that you put to us is the right challenge, which is it’s very difficult when finances are tight, as they are in all of our countries.” On Tuesday morning the Prime Minister will meet Taavi Madiberk, the founder of Estonian tech start-up manufacturing low-cost air defence missiles, Frankenburg Technologies, which is planning to open a new office in London Specialising in the manufacture of the missiles, the rapidly growing company already collaborates closely with the UK defence industry, sourcing a significant portion of its subsystems locally, including from propulsion specialists Roxel in Worcestershire. The Prime Minister will again attend the JEF summit, joining leaders from the Nordics and Baltics to discuss support for Ukraine, the sustained threat posed by Russia and wider European security. He will then visit British forces serving in the region to deter malign Russian threats.

BOSTON (AP) — Two men, including a dual Iranian American citizen, have been arrested on charges that they exported sensitive technology to Iran that was used in a drone attack in Jordan that killed three American troops early this year and injured dozens of other service members, the Justice Department said Monday. The pair were arrested after FBI specialists who analyzed the drone traced the navigation system to an Iranian company operated by one of the defendants, who relied on technology funneled from the U.S. by his alleged co-conspirator, officials said. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

Schieffelin has 18 points, 13 rebounds and 8 assists as Clemson hands Penn State first loss 75-67Will Utah State or Boise State forfeit vs. San Jose State in the Mountain West semifinals?Noem proposes $7.3B for South Dakota's new budget; calls for school savings accounts, budget cuts

LAS VEGAS , Dec. 16, 2024 /PRNewswire/ -- CTLA-4 inhibitors are a well-established market in cancer care, and they are expected to grow significantly in the coming years. This is due to the expected label expansion and usage of the blockbuster YERVOY and an increasing number of new clinical studies evaluating better-acting versions of CTLA-4 inhibitors in various types of cancers. Other market drivers include increased usage of CTLA-4 inhibitors in combination with other immune checkpoint inhibitors and the increasing prevalence of cancer cases. DelveInsight's CTLA-4 Inhibitors Market Insights report includes a comprehensive understanding of current treatment practices, emerging CTLA-4 inhibitors, market share of individual therapies, and current and forecasted CTLA-4 inhibitors market size from 2020 to 2034, segmented into 7MM [ the United States , the EU4 ( Germany , France , Italy , and Spain ), the United Kingdom , and Japan ]. Key Takeaways from the CTLA-4 Inhibitors Market Report As per DelveInsight's analysis, the total market size of CTLA-4 inhibitors in the 7MM is expected to surge significantly by 2034. In 2023, YERVOY registered global sales of more than USD 2 billion , followed by IMJUDO which closed 2023 with more than USD 200 million in global sales. YERVOY in combination with OPDIVO is approved for multiple indications in first-line settings including metastatic Melanoma, mesothelioma, Renal Cell Carcinoma, NSCLC, Esophageal cancer, Gastric Cancer, and other second-line indications. There are other newer indications where the combo is being evaluated. Established CTLA-4 inhibitor companies include Bristol Myers Squibb (BMS) and AstraZeneca, Leading emerging CTLA-4 inhibitor companies such as Merck , Xilio therapeutics, BioNTech, Agenus, Bioatla OncoC4, and others are developing novel CTLA-4 inhibitors that can be available in the CTLA-4 inhibitors market in the coming years. Some of the key CTLA-4 inhibitors in the pipeline include Quavonlimab (MK-1308), gotistobart ( ONC-392/BN316 ), BA3071 , and others. Discover which therapies are expected to grab the CTLA-4 inhibitors market share @ CTLA-4 Inhibitors Market Report CTLA-4 Inhibitors Market Dynamics In recent years, the CTLA-4 inhibitors market has been shaped by significant advances in cancer immunotherapy. The growing use of combination therapies , particularly the pairing of CTLA-4 inhibitors with PD-1/PD-L1 inhibitors (like nivolumab or pembrolizumab), has transformed the treatment landscape for several cancers, including melanoma, renal cell carcinoma, and non-small cell lung cancer (NSCLC). This combination approach has demonstrated improved survival benefits , broadening the market for CTLA-4 inhibitors beyond their original monotherapy applications. Additionally, research is ongoing to explore the use of these drugs in other cancers such as colorectal and pancreatic cancer, further fueling market growth. However, market dynamics are influenced by several factors, including the high cost of immunotherapy treatments and the side effects associated with CTLA-4 inhibitors . Immune-related adverse events (irAEs) like colitis, hepatitis, and dermatitis are common due to the drug's effect of ramping up immune activity. As a result, healthcare providers are cautious in prescribing these treatments , and pharmaceutical companies are working on optimizing dosing regimens and exploring biomarkers that could predict which patients will respond best to CTLA-4 inhibition. These considerations impact pricing, regulatory approval, and overall market uptake. The competitive landscape is also heating up as more pharmaceutical companies enter the immunotherapy space. While Bristol- Myers Squibb's ipilimumab has dominated the market, new players and biosimilars are emerging. Additionally, research into next-generation CTLA-4 inhibitors and alternative immune checkpoint targets (like LAG-3 and TIGIT) could change the market dynamics further. The evolution and improvisation of this class can be seen through the development of Fc-enhanced tumor-activated anti-CTLA-4 inhibitors (Xilio's Therapeutics' Vilastobart) which also deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME). The innovations in drug delivery and therapeutic combinations , is likely to drive new developments in this area, attracting substantial investment and strategic partnerships. Overall, the CTLA-4 inhibitors market remains highly promising, buoyed by the increasing global burden of cancer , the expanding role of immunotherapy in oncology, and the significant unmet need in the treatment of several aggressive cancers. Advances in research and clinical trials , along with ongoing regulatory approvals, are expected to keep this market growing in the foreseeable future. However, balancing efficacy, safety, and cost will be critical for both pharmaceutical companies and healthcare providers to ensure the sustained success of CTLA-4 inhibitors. CTLA-4 Inhibitors Treatment Market Approved CTLA-4 inhibitors at present are YERVOY (ipilimumab) and IMJUDO (tremelimumab-actl). In March 2011 , YERVOY was the first cancer immunotherapy approved for melanoma, specifically targeting CTLA-4. At that time, it was the only approved treatment for unresectable or metastatic melanoma that showed a significant enhancement in overall survival. The FDA's approval of YERVOY represents the result of over 14 years of research and development by BMS teams, as well as clinical trials involving 676 patients with unresectable or metastatic melanoma who had previously received one or more treatments, including aldesleukin, dacarbazine, temozolomide, fotemustine, or carboplatin, in a randomized Phase III clinical trial. IMJUDO is a human monoclonal antibody designed to inhibit the activity of CTLA-4. By blocking CTLA-4, it promotes T-cell activation, which enhances the immune response against cancer and encourages the destruction of cancer cells. With its initial regulatory approval, patients in the US suffering from unresectable liver cancer now have access to an approved dual immunotherapy treatment regimen that uniquely combines CTLA-4 inhibition with a PD-L1 inhibitor, thereby amplifying the immune response to their cancer. YERVOY currently leads the CTLA-4 inhibitor market, generating over USD 2 billion in sales in 2023, while IMJUDO ended the year with sales exceeding USD 200 million . However, numerous CTLA-4 inhibitors are in clinical trials, with some utilizing innovative proprietary technologies in their development, which could pose a significant challenge to YERVOY's market dominance in the future. Learn more about the FDA-approved CTLA-4 inhibitors @ CTLA-4 Inhibitors Drugs Key Emerging CTLA-4 Inhibitors and Companies Several key emerging players, including Merck, BioNTech, Agenus, BioAtla , and others, are involved in developing drugs for CTLA-4 inhibitors for various indications such as metastatic castration-resistant prostate cancer, breast cancer, cervical cancer, non-squamous cell lung cancer, and others. OncoC4/BioNTech's BNT316/ONC-392 (gotistobart) is a next-generation anti-CTLA-4 antibody being co-developed by BioNTech and OncoC4. It is in late-stage clinical trials, either as a monotherapy or in combination with other treatments, targeting various cancers including non-small cell lung cancer, ovarian cancer, high-grade serous adenocarcinoma of the ovary, primary peritoneal carcinoma, and fallopian tube cancer. CTLA-4 is an immune checkpoint receptor that suppresses T cell responses, limiting their ability to identify and destroy cancer cells. Gotistobart is designed to counteract this suppression while maintaining CTLA-4 recycling, which helps preserve T cell immunosuppressive function in peripheral tissues. This approach, now under clinical evaluation, aims to reduce immune-related side effects. BioAtla's BA3071 is a conditionally active biologic (CAB) anti-CTLA-4 antibody being developed as an immuno-oncology agent. It aims to provide efficacy comparable to existing anti-CTLA-4 antibodies, but with reduced toxicity due to its selective activity in the tumor microenvironment. While blocking CTLA-4 has been shown to enhance antitumor responses, it can also cause immune-related damage to healthy cells. To reduce this risk of on-target, off-tumor effects, BioAtla has used its proprietary CAB technology to ensure that BA3071 binds to the CTLA-4 receptor only on T cells within the tumor microenvironment. This design is intended to enhance both the efficacy and safety of anti-CTLA-4 therapy, whether used alone or in combination with other treatments, by activating T cells specifically in the tumor site. BA3071 is currently in Phase II trials for treating various solid tumors that respond to CTLA-4 inhibition in combination with a PD-1 blocking agent. The anticipated launch of these emerging therapies are poised to transform the CTLA-4 inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the CTLA-4 inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth. To know more about CTLA-4 inhibitors clinical trials, visit @ CTLA-4 Inhibitors Treatment Drugs CTLA-4 Inhibitors Overview CTLA-4 inhibitors are a class of immune checkpoint inhibitors that target cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), a protein expressed in T cells. CTLA-4 plays a crucial role in downregulating immune responses by binding to B7 molecules on antigen-presenting cells (APCs), which suppresses T-cell activation. By inhibiting CTLA-4, these drugs block the suppression of T cells, thereby enhancing the immune system's ability to recognize and destroy cancer cells. This mechanism has made CTLA-4 inhibitors an essential part of cancer immunotherapy, particularly in treating advanced-stage malignancies like melanoma. Ipilimumab, the first approved CTLA-4 inhibitor, has shown significant survival benefits in clinical trials, leading to its use in combination with other immune checkpoint inhibitors, such as PD-1 inhibitors, to further improve patient outcomes. While CTLA-4 inhibitors have shown promise in cancer therapy, their use comes with challenges, particularly immune-related adverse events (irAEs). These adverse effects occur because the inhibition of CTLA-4 can lead to excessive immune activation, which may result in the immune system attacking normal tissues and organs. Common irAEs include colitis, dermatitis, and hepatitis. Managing these side effects requires a delicate balance between maintaining the anti-cancer immune response and mitigating harmful autoimmune reactions. Despite these challenges, the clinical benefits of CTLA-4 inhibitors have made them a vital component in the fight against cancer, driving ongoing research into their optimization and use in combination therapies. Scope of the CTLA-4 Inhibitors Market Report CTLA-4 Inhibitors Therapeutic Assessment: CTLA-4 Inhibitors current marketed and emerging therapies CTLA-4 Inhibitors Market Dynamics: Conjoint Analysis of Emerging CTLA-4 Inhibitors Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies Unmet Needs, KOL's views, Analyst's views, CTLA-4 Inhibitors Market Access and Reimbursement Discover more about CTLA-4 inhibitors in development @ CTLA-4 Inhibitors Clinical Trials Table of Contents Related Reports Non-small Cell Lung Cancer Market Non-small Cell Lung Cancer Market Insight, Epidemiology and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key NSCLC companies, including EMD Serono, Merck, Cellular Biomedicine Group, Inc., Celgene, CellSight Technologies, Inc., BeyondSpring Pharmaceuticals Inc., J Ints Bio, Forward Pharmaceuticals Co., Ltd., AstraZeneca, Bristol-Myers Squibb, Teligene US, Rain Oncology Inc, ReHeva Biosciences, Inc., Amgen, Novartis, RedCloud Bio, Parexel, Vitrac Therapeutics, LLC, Mythic Therapeutics, Instil Bio, Mirati Therapeutics Inc., Daiichi Sankyo, Inc., AstraZeneca, Precision Biologics, Inc, Promontory Therapeutics Inc., Palobiofarma SL, Regeneron Pharmaceuticals, Revolution Medicines, Inc., Cullinan Oncology, LLC, Iovance Biotherapeutics, Inc., Innate Pharma , among others. Non-small Cell Lung Cancer Pipeline Non-small Cell Lung Cancer Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key non-small cell lung cancer companies, including BridgeBio Pharma, Daiichi Sankyo, EMD Serono, Merck, BridgeBio Pharma, Abbvie, Pfizer, Eli Lilly and Company BioNTech SE, Shenzhen TargetRx, Taiho Pharmaceutical, Chong Kun Dang , Bristol Myers Squibb, Innovent Biologics, Xuanzhu Biopharmaceutical, Bayer, GeneScience Pharmaceuticals, InventisBio, Apollomics, Imugene, Ono Pharmaceutical, Pierre Fabre , Jiangsu Hengrui Medicine Co., Bristol-Myers Squibb, Surface Oncology, Inhibrx, Sinocelltech, Mirati Therapeutics, REVOLUTION Medicines, Yong Shun Technology Development, Iovance Biotherapeutics, Galecto Biotech, among others. Ovarian Cancer Market Ovarian Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, market share of the individual therapies, and key ovarian cancer companies including Allarity Therapeutics, OSE Immunotherapeutic, Cristal Therapeutics, Bristol-Myers Squibb, Ono Pharmaceuticals, Merck & Co, Aravive Biologics, Mersana Therapeutics, Clovis Oncology, Verastem Oncology, Gradalis, VBL Therapeutics, AbbVie, Elevation oncology, OncoQuest Pharmaceuticals (CanariaBio), Alkermes, Hoffman-la Roche, AstraZeneca, MSD, GlaxoSmithKline, IMV, Corcept Therapeutics , among others. Ovarian Cancer Pipeline Ovarian Cancer Pipeline Insight – 2024 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key ovarian cancer companies, including Gradalis, VBL Therapeutics, AbbVie, Elevation oncology, OncoQuest Pharmaceuticals (CanariaBio), Alkermes, Hoffman-la Roche, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +14699457679 Logo: https://mma.prnewswire.com/media/1082265/3528414/DelveInsight_Logo.jpg SOURCE DelveInsight Business Research, LLPNone

Raima Sen mourns Bharat Dev Varma's demise, pens emotional note for 'great father, great husband'

In a bombshell revelation, veteran Sydney Swans senior coach John Longmire is reportedly ‘quitting’, with a club announcement coming on Tuesday. Watch every game of the NAB AFL Women’s Finals Series LIVE with no ad-breaks during play on Kayo. New to Kayo? Get your first month for just $1. Limited time offer. Longmire has a year to run on his current contract, but according to Nine’s Tom Morris , the 53-year-old is set to announce his resignation from the role. The 14-year mentor met with senior Sydney players on Tuesday to discuss his future, per Seven’s Mitch Cleary . The Swans have scheduled a ‘major club announcement’ for 1:30pm. Morris added Longmire’s call was only made ‘in the last week or two’ amid a long-mooted succession plan involving right-hand man Dean Cox. SEN reporter Sam Edmund said the news had been communicated to Longmire’s ‘inner circle’ in recent days. “Next season was most likely to be his last year — that’s what those close to John Longmire were saying — but certainly, in the last three-to-four days, a decision has been made by ‘Horse’ himself and communicated to his inner circle over the weekend,” Edmund told SEN . “The players are being informed today en masse that their coach will be resigning today, effective immediately ... and then we await confirmation that Dean Cox — the assistant coach who was such a person of interest for the West Coast position — will take charge.” As coach, Longmire coached Sydney to a premiership in his second year in charge but has since gone on to post a 1-4 record in grand finals — including this year’s demoralising 60-point defeat to the Brisbane Lions. Longmire holds an overall record of 194-3-108 and a winning clip of 64.1 per cent. MORE TO COME.Titans S Julius Wood suspended 6 games for PEDs

Alabama flips RB Jace Clarizio from Michigan StateAs the residential real estate market in Japan seems to be in an expansionary phase and condominium prices in central Tokyo continue to notch records every month, foreign interest in residential property is also growing at a breakneck speed. Whatever the reason for your interest, you have come to the right place to learn more about whether buying a home in Japan is right for you. In this webinar, presented by Dovetail Inc, a bilingual brokerage based in Tokyo, attendees will have a chance to get a comprehensive overview of the Japanese residential property market and get answers to their questions. Dovetail is a new and fast-growing brokerage located in central Tokyo. Their team includes a bilingual agent with five years experience in brokerage as well as staff experienced in housing support services for foreigners. Their staff can guide foreign buyers through the purchase journey, from initial fact-finding and needs analysis to explaining cultural nuances, tax rules and all the minutiae involved in purchasing a property as a foreigner. As their name suggests, the Dovetail team prides itself on streamlining and harmonizing the purchase process, with the goal of making your home buying journey as seamless as possible. Join them for this very special kick-off presentation on how to buy a home in Japan as a foreigner. December 11, 6 p.m. to 7 p.m. (Japan Standard Time) Yasuhiro Kitagawa / CEO Company: Dovetail Inc Yasuhiro leads Dovetail offering bilingual real estate brokerage services enhanced by technology and the Gakken Group. Through Dovetail, he aims to help people build structure in their lives, unlocking greater possibilities. With a focus on innovation and connection, he strives to make real estate transitions seamless and impactful. Please click " Register Now " and fill in the Google form. A dedicated webinar link will be sent to you after you register.

U.S. Sen. Kelly Loeffler (R-GA) welcomes a crowd during a runoff election night party at Grand Hyatt Hotel in Buckhead on January 6, 2021 in Atlanta, Georgia. (Photo by Brandon Bell/Getty Images) ATLANTA - President-elect Donald Trump announced on Wednesday that he will nominate former U.S. Senator Kelly Loeffler to serve as the head of the Small Business Administration (SBA) in his upcoming administration. In a post on his social media platform, Truth Social, Trump praised Loeffler’s extensive experience in business and government. He emphasized her skills in streamlining operations and fostering growth for small businesses, which he described as 'the backbone of our great economy.' "Kelly will bring her experience in business and Washington to reduce red tape, and unleash opportunity for our Small Businesses to grow, innovate, and thrive," Trump wrote. "She will focus on ensuring that SBA is accountable to Taxpayers by cracking down on waste, fraud, and regulatory overreach." Georgia Gov. Brian Kemp appointed Loeffler to the U.S. Senate in December 2019 after Sen. Johnny Isakson resigned due to health issues. She served until January 2021 but was defeated in a special election by Democrat Raphael Warnock in a January 2021 runoff. Trump commended her work on legislation aimed at protecting women in sports. Prior to her political career, Loeffler spent 25 years in financial services and technology. As Executive Vice President, she contributed to the growth of a company that expanded from 100 employees to over 10,000 and achieved Fortune 500 status. "Kelly was a tremendous fighter in the U.S. Senate," Trump said. "Along with her amazing husband, Jeff, she helped build a Fortune 500 company and played a crucial role in securing my Big Election Win in Georgia." Upon confirmation, Loeffler would oversee the agency tasked with aiding, counseling, assisting, and protecting the interests of small business concerns and helping families and businesses recover from national and other declared disasters. A native of Illinois, Loeffler moved to Georgia in the early 2000s and quickly rose to prominence in the state's business and political scenes. She and her husband, Jeffrey Sprecher, co-own the Atlanta Dream, a WNBA team, and have been active Republican donors. Loeffler is currently a co-chair of Trump's inaugural committee. The Source: The naming of former Sen. Kelly Loeffler was announced by President-elect Donald Trump on his social media platform Truth Social. Details about Loeffler's life and career were compiled using previous reports by FOX 5 Atlanta, the Associated Press, and FOX News.NEW YORK (AP) — As she anticipates her estranged uncle's return to the White House, Mary Trump isn't expecting any future book to catch on like such first-term tell-alls as Michael Wolff's million-selling “Fire and Fury” or her own blockbuster, “Too Much and Never Enough.” “What else is there to learn?” she says. “And for people who don't know, the books have been written. It's all really out in the open now.” For publishers, Donald Trump's presidential years were a time of extraordinary sales in political books, helped in part by Trump's legal threats and angered tweets. According to Circana, which tracks around 85% of the hardcover and paperback market, the genre's sales nearly doubled from 2015 to 2020, from around 5 million copies to around 10 million. Besides books by Wolff and Trump, other bestsellers included former FBI Director James Comey's “A Higher Loyalty,” former national security adviser John Bolton's “The Room Where it Happened” and Bob Woodward's “Fear.” Meanwhile, sales for dystopian fiction also jumped, led by Margaret Atwood's “A Handmaid's Tale,” which was adapted into an award-winning Hulu series. But interest has dropped back to 2015 levels since Trump left office, according to Circana, and publishers doubt it will again peak so highly. Readers not only showed little interest in books by or about President Joe Biden and his family — they even seemed less excited about Trump-related releases. Mary Trump's “Who Could Ever Love You” and Woodward's “War” were both popular this fall, but neither has matched the sales of their books written during the first Trump administration. “We’ve been there many times, with all those books,” HarperCollins publisher Jonathan Burnham says of the various Trump tell-alls. He added that he still sees a market for at least some Trump books — perhaps analyzing the recent election — because “there's a general, serious smart audience, not politically aligned in a hard way,” one that would welcome “an intelligent voice.” “It’s like the reboot of any hit TV show,” says Eric Nelson, publisher and vice president of Broadside Books, a conservative imprint of HarperCollins that's released books by Jared Kushner, Florida Gov. Ron DeSantis and Trump Cabinet nominees Pete Hegseth and Sen. Marco Rubio. “You’re not hoping for ratings like last time, just better ratings than the boring show it’s replacing.” In the days following Trump's victory, “The Handmaid's Tale” and George Orwell's “1984” returned to bestseller lists, along with more contemporary works such as Timothy Snyder's “On Tyranny," a 2017 bestseller that expanded upon a Facebook post Snyder wrote soon after Trump defeated Hillary Clinton. Books appealing to pro-Trump readers also surged, including those written by Cabinet picks — Robert F. Kennedy Jr.'s “The Real Anthony Fauci” and Hegseth's “The War on Warriors” — and Vice President-elect J.D. Vance's “Hillbilly Elegy,” his 2016 memoir that's sold hundreds of thousands of copies since Trump selected him as his running mate. First lady Melania Trump's memoir, “Melania,” came out in October and has been high on Amazon.com bestseller lists for weeks, even as critics found it contained little newsworthy information. According to Circana, it has sold more than 200,000 copies, a figure that does not include books sold directly through her website. “The Melania book has done extraordinarily well, better than we thought,” says Barnes & Noble CEO James Daunt. “After Election Day, we sold everything we had of it.” Conservative books have sold steadily over the years, and several publishers — most recently Hachette Book Group — have imprints dedicated to those readers. Publishers expect at least some critical books to reach bestseller lists — if only because of the tradition of the publishing market favoring the party out of power. But the nature of what those books would look like is uncertain. Perhaps a onetime insider will have a falling out with Trump and write a memoir, like Bolton or former Trump attorney Michael Cohen, or maybe some of his planned initiatives, whether mass deportation or the prosecution of his political foes, will lead to investigative works. A new “Fire and Fury” is doubtful, with the originally only possible because Wolff enjoyed extraordinary access, spending months around Trump and his White House staff. Members of the president-elect's current team have already issued a statement saying they have refused to speak with Wolff, calling the author a “known peddler of fake news who routinely concocts situations, conversations, and conclusions that never happened.” A publicist for Wolff said he was declining comment. Woodward, who interviewed Trump at length for the 2020 bestseller “Rage,” told The Associated Press that he had written so much about Trump and other presidents that he wasn't sure what he'd take on next. He doesn't rule out another Trump book, but that will depend in part on the president-elect, how “out of control he gets,” Woodward said, and how far he is able to go. “He wants to be the imperial president, where he gets to decide everything and no one's going to get in his way,” Woodward said. “He's run into some brick walls in the past and there may be more brick walls. I don't know what will happen. I'll be watching and doing some reporting, but I'm still undecided.” 1. “Too Much and Never Enough,” by Mary Trump: 1,248,212 copies 2. “Fire and Fury,” by Michael Wolff: 936,116 copies 3. “Fear,” by Bob Woodward: 872,014 copies 4. “The Room Where It Happened,” by John Bolton: 676,010 copies 5. “Rage,” by Bob Woodward: 549,685 copies These figures represent total sales provided by Circana, which tracks about 85% of the print market and does not include e-book or audiobook sales.Stephen Robinson's Aberdeen praise but St Mirren boss believes in his BuddiesNone

Who Is David Bakhtiari’s Wife? Frankie Shebby’s Relationship History ExplainedNone

Middle East latest: Israeli strikes on Gaza hospital wound 3, Netanyahu vows 'iron fist' in Lebanon

Clinton presses past University High in Hardee's openerGoogle’s Gemini 2.0 May Signal the Future of AI AgentsIsraeli drone strikes hit Kamal Adwan Hospital on Tuesday, wounding three medical staff at one of the few hospitals still partially operating in the northernmost part of Gaza , the facility’s director said. Dr. Hossam Abu Safiya said the drones were dropping bombs, spraying shrapnel at the hospital. There was no immediate comment from the Israeli military. In Lebanon, a tenuous ceasefire between Israel and Hezbollah has held despite Israeli forces carrying out several new drone and artillery strikes on Tuesday, killing a shepherd in the country's south. Israeli Prime Minister Benjamin Netanyahu vowed keep striking “with an iron fist” against perceived Hezbollah violations of the ceasefire. Hezbollah began launching rockets, drones and missiles into Israel last year in solidarity with Hamas militants who are fighting in the Gaza Strip. The war in Gaza began when Hamas-led militants stormed into southern Israel on Oct. 7, 2023, killing some 1,200 people, mostly civilians, and taking around 250 people hostage . Israel’s blistering retaliatory offensive has killed at least 44,500 Palestinians , more than half of them women and children, according to Gaza’s Health Ministry, which does not say how many of the dead were combatants. Israel says it has killed over 17,000 militants, without providing evidence. The war in Gaza has destroyed vast areas of the coastal enclave and displaced 90% of the population of 2.3 million, often multiple times . Here's the Latest: US forces in eastern Syria conduct a self-defense strike, Pentagon says WASHINGTON — U.S. forces conducted a self-defense strike Tuesday in the vicinity of Mission Support Site Euphrates, a U.S. base in eastern Syria, against three truck-mounted multiple rocket launchers, a T-64 tank and mortars that Pentagon press secretary Maj. Gen. Pat Ryder said presented “a clear and imminent threat” to U.S. troops. The self-defense strike occurred after rockets and mortars were fired that landed in the vicinity of the base, Ryder said. The Pentagon is still assessing who was responsible for the attacks — that there are both Iranian-backed militias and Syrian military forces that operate in the area. Ryder said the attack was not connected to the offensive that is ongoing in Aleppo, where Syrian jihadi-led rebels taken over the country’s largest city. The U.S. has about 900 troops in Syria to conduct missions to counter the Islamic Stage group. Israeli drone strikes hit a hospital in northern Gaza, wounding 3 medical staff CAIRO — Israeli drone strikes hit the Kamal Adwan Hospital in northern Gaza on Tuesday, wounding three medical personnel, the facility’s director said. Dr. Hossam Abu Safiya said the drones were dropping bombs, spraying shrapnel at the hospital, located in the town of Beit Lahiya. There was no immediate comment from the Israeli military. In comments released by Gaza’s Health Ministry, Abu Safiya said one of the injured was in critical condition and was undergoing a complex surgery. “The situation has become extremely dangerous,” he said. “We are exhausted by the ongoing violence and atrocities.” Kamal Adwan Hospital has been struck multiple times over the past two months as Israeli forces have waged a fierce offensive in the area, saying they are rooting out Hamas militants who regrouped there. In October, Israeli forces raided the hospital, saying that militants were sheltering inside and arrested a number of people, including some staff. Hospital officials denied the claim. Abu Safiya was wounded in his thigh and back by an Israeli drone strike on the hospital last month. Israeli court orders Netanyahu to take the stand in his long-running corruption trial TEL AVIV, Israel — An Israeli court has ordered Prime Minister Benjamin Netanyahu to take the stand next week in his long-running corruption trial, ending a long series of delays. Netanyahu’s lawyers had filed multiple requests to put off the testimony, arguing first that the war in Gaza prevented him from properly preparing for his testimony, and later that his security could not be guaranteed in the court chamber. In Tuesday’s decision, judges in the Jerusalem district court said that following a security assessment, his testimony will be moved to the Tel Aviv district court. Israeli media said the session would take place in an underground chamber. His testimony in the trial, which began in 2020, is expected to begin on Dec. 10 and to last at least several weeks. Netanyahu is charged with fraud, breach of trust and accepting bribes in three separate scandals involving powerful media moguls and wealthy associates. He denies wrongdoing. Lebanese civilians who came back to war-damaged towns are skeptical that Israel will abide by the ceasefire NABATIYEH, Lebanon — In destroyed areas of southern Lebanon, residents clearing away rubble on Tuesday said they didn’t trust Israel to abide by the week-old ceasefire with Hezbollah. “The Israelis are breaching the ceasefire whenever they can because they are not committed,” said Hussein Badreddin, a vegetable seller in the southern city of Nabatiyeh, which was pummeled by Israeli airstrikes over several weeks. “This means that they (can) breach any resolution at any time.” Since it began last Wednesday, the U.S.- and French-brokered 60-day ceasefire has been rattled by near daily Israeli strikes, although Israel has been vague about the purported Hezbollah violations that prompted them. Imad Yassin, a trader who owns a clothing shop in Nabatiyeh, said Israel was constantly breaching the ceasefire because Israeli Prime Minister Benjamin Netanyahu wants to continue the displacement of residents of southern Lebanon. “The Israeli enemy was defeated and the truth is that he is trying to get revenge. Netanyahu is trying to displace us as citizens of southern Lebanon,” Yassin said. They spoke as bulldozers cleared streets strewn with rubble and debris from destroyed buildings. Electricians worked to fix power lines in an effort to restore electricity to the city. Both men were displaced by the war and returned to Nabatiyeh on Wednesday, the day the ceasefire went into effect. Yassin found his clothing shop had been destroyed. He said he would wait to see if the state will dispense compensation funds so that he can repair and reopen his business. Israeli strikes kill at least 9 people in Gaza City GAZA CITY, Gaza Strip — Two separate Israeli airstrikes killed at least nine people in Gaza City on Tuesday, Palestinian medical authorities said. Six people, including two children, who were killed when an Israeli strike hit a school sheltering displaced people Tuesday afternoon in the Zaytoun neighborhood, according to the Health Ministry’s emergency services. A second strike hit a residential building in the Sabra neighborhood, killing at least three people, the services said. Israeli forces have almost completely isolated northernmost Gaza since early October, saying they’re fighting regrouped Hamas militants there. That has pushed some families south to Gaza City, while hundreds of thousands more live in the territory's center and south in squalid tent camps, where they rely on international aid. Israel says it killed a Hezbollah representative to the Syrian military JERUSALEM — Israel's military confirmed it killed a senior member of Hezbollah responsible for coordinating with Syria's army on rearming and resupplying the Lebanese militant group. Syrian state media said a drone strike on Tuesday hit a car in a suburb of the capital Damascus, killing one person, without saying who was killed. Israel's military said he was Salman Nemer Jomaa, describing him as “Hezbollah’s representative to the Syrian military,” and that killing him “degrades both Hezbollah’s presence in Syria and Hezbollah’s ongoing force-building efforts.” Israel has carried out hundreds of strikes on targets inside government-controlled parts of war-torn Syria in recent years. Israel rarely acknowledges its actions in Syria, but it has said that it targets bases of Iran-allied militant groups. Iran supports both Hezbollah and the Syrian government of President Bashar Assad, which is currently fighting to push back jihadi-led insurgents who seized the country’s largest city of Aleppo . Israeli soldiers open fire inside a West Bank hospital while searching for militants' bodies, doctor says TUBAS, West Bank — Israeli soldiers opened fire inside a hospital in the occupied West Bank on Tuesday during a raid to seize the bodies of alleged militants targeted in earlier airstrikes, a Palestinian doctor working at the hospital told The Associated Press. Soldiers entered the Turkish Hospital complex in Tubas after the bodies of two Palestinians killed and one wounded in airstrikes in the northern West Bank on Tuesday were brought there, said Dr. Mahmoud Ghanam, who works in the hospital’s emergency department. The troops briefly handcuffed and arrested Ghanam and another doctor. “The army entered in a brutal way, and they were shooting inside the emergency department,” said Ghanam. “They handcuffed us and took me and my colleague.” The military confirmed that its troops were operating around the hospital searching for those targeted in the airstrikes, which they said had hit a militant cell near the Palestinian town of Al-Aqaba in the Jordan Valley. It denied that troops had entered the hospital building or fired gunshots inside. The soldiers left after learning that the wounded man had been transferred to another hospital, Ghanam said. The soldiers wanted to take the bodies of the two men killed in the strike, but the hospital’s manager refused to hand over the bodies, Ghanam said. Israeli raids on hospitals in the West Bank are rare but have grown more common since the start of the Israel-Hamas war. In Gaza, Israeli troops have systematically besieged, raided and damaged many hospitals. About 800 Palestinians have been killed by Israeli fire in the West Bank since Hamas’ Oct. 7, 2023 attack out of Gaza ignited the war there. Israel has carried out near-daily military raids in the West Bank that it says are aimed at preventing attacks on Israelis — attacks which have also been on the rise. Israel captured the West Bank, the Gaza Strip and east Jerusalem in the 1967 Mideast war. The Palestinians seek all three territories for an independent state. Hamas and Fatah are near an agreement on who will oversee postwar Gaza CAIRO — Palestinian officials say Fatah and Hamas are closing in on an agreement to appoint a committee of politically independent technocrats to administer the Gaza Strip after the war . It would effectively end Hamas’ rule and could help advance ceasefire talks with Israel. The rival factions have made several failed attempts to reconcile since Hamas seized power in Gaza in 2007. Israel has meanwhile ruled out any postwar role in Gaza for either Hamas or Fatah, which dominates the Western-backed Palestinian Authority . A Palestinian Authority official on Tuesday confirmed that a preliminary agreement had been reached following weeks of negotiations in Cairo. The official said the committee would have 12-15 members, most of them from Gaza. It would report to the Palestinian Authority, which is headquartered in the Israeli-occupied West Bank, and work with local and international parties to facilitate humanitarian assistance and reconstruction. A Hamas official said that Hamas and Fatah had agreed on the general terms but were still negotiating over some details and the individuals who would serve on the committee. The official said an agreement would be announced after a meeting of all Palestinian factions in Cairo, without providing a timeline. Both officials spoke on condition of anonymity because they were not authorized to brief media on the talks. There was no immediate comment from Israel. Israeli Prime Minister Benjamin Netanyahu has vowed to continue the war until Hamas is dismantled and scores of hostages are returned. He says Israel will maintain open-ended security control over Gaza , with civilian affairs administered by local Palestinians unaffiliated with the Palestinian Authority or Hamas. No Palestinians have publicly volunteered for such a role, and Hamas has threatened anyone who cooperates with the Israeli military. The United States has called for a revitalized Palestinian Authority to govern both the West Bank and Gaza ahead of eventual statehood. The Israeli government is opposed to Palestinian statehood. Associated Press writers Samy Magdy in Cairo and Josef Federman in Jerusalem contributed. Palestinians get food aid in central Gaza, some for the first time in months NUSEIRAT REFUGEE CAMP, Gaza Strip — Palestinians lined up for bags of flour distributed by the U.N. in central Gaza on Tuesday morning, some of them for the first time in months amid a drop in food aid entering the territory. The U.N. agency for Palestinian refugees, known as UNRWA, gave out one 25-kilogram flour bag (55 pounds) to each family of 10 at a warehouse in the Nuseirat refugee camp, as well as further south in the city of Khan Younis. Jalal al-Shaer, among the dozens receiving flour at the Nuseirat warehouse, said the bag would last his family of 12 for only two or three days. “The situation for us is very difficult,” said another man in line, Hammad Moawad. “There is no flour, there is no food, prices are high ... We eat bread crumbs.” He said his family hadn’t received a flour allotment in five or six months. COGAT, the Israeli army body in charge of humanitarian affairs, said it facilitated entry of a shipment of 600 tons of flour on Sunday for the World Food Program. Still, the amount of aid Israel has allowed into Gaza since the beginning of October has been at nearly the lowest levels of the 15-month-old war. UNRWA’s senior emergency officer Louise Wateridge told The Associated Press that the flour bags being distributed Tuesday were not enough. “People are getting one bag of flour between an entire family and there is no certainty when they’ll receive the next food,” she said. Wateridge added that UNRWA has been struggling like other humanitarian agencies to provide much needed supplies across the Gaza Strip. The agency this week announced it was stopping delivering aid entering through the main crossing from Israel, Kerem Shalom, because its convoys were being robbed by gangs. UNRWA has blamed Israel in large part for the spread of lawlessness in Gaza. The International Criminal Court is seeking to arrest Israeli Prime Minister Benjamin Netanyahu and his former defense minister over accusations of using “starvation as a method of warfare” by restricting humanitarian aid into Gaza. Israel rejects the allegations and says it has been working hard to improve entry of aid. Netanyahu vows an ‘iron fist’ against Hezbollah if they break the ceasefire, and thanks Trump for tough talk on Gaza hostages JERUSALEM — Israeli Prime Minister Benjamin Netanyahu says the war isn't over against Hezbollah and vowed to use "an iron fist" against the Lebanese militant group for any perceived violations of a week-old ceasefire. “At the moment we are in a ceasefire, I note — a ceasefire, not the end of the war," Netanyahu said at the start of the government meeting Tuesday. He said the military would retaliate for “any violation — minor or major.” Netanyahu also thanked U.S. President-elect Donald Trump for his recent demands for Hamas to release the remaining Israeli hostages in Gaza. Trump posted on social media Monday that if the hostages are not freed before he takes office in January there would be “HELL TO PAY.” Netanyahu convened Tuesday's meeting in northern Israel, where around 45,000 Israelis had been displaced by the war as of last week, according to the prime minister’s office. Netanyahu said the government was focused on getting them back in their homes and rehabilitating the area. Germany arrests a Lebanese man accused of being a member of Hezbollah BERLIN — German authorities have arrested a Lebanese man accused of being a member of Hezbollah and working for groups controlled by the militant organization in Germany. Federal prosecutors said the suspect, identified only as Fadel R. in line with German privacy rules, was arrested in the Hannover region on Tuesday. The man is suspected of membership in a foreign terrorist organization and is not accused of direct involvement in any violence. Prosecutors said he joined Hezbollah in the summer of 2008 or earlier and took part in leadership training courses in Lebanon. From 2009, he allegedly had leadership duties in two groups controlled by Hezbollah in the Hannover area, organizing appearances by preachers close to the militants. According to prosecutors, he was briefly a correspondent for a Hezbollah media outlet in 2017 and was tasked with coordinating building work at a mosque. Germany is a staunch ally of Israel. It is also home to a Lebanese immigrant community of more than 100,000. Lebanese army launches recruitment drive to bolster presence in the south BEIRUT — The Lebanese army is looking for more recruits as it beefs up its presence in southern Lebanon after the Israel-Hezbollah ceasefire. Lebanon’s army is a respected national institution that kept to the sidelines during the nearly 14-month conflict. During an initial 60-day truce, thousands of Lebanese troops are supposed to deploy in southern Lebanon, where U.N. peacekeepers also have a presence. Hezbollah militants are to pull back from areas near the border as Israel withdraws its ground forces. The army said those interested in joining up have a one-month period to apply, starting Tuesday. The Lebanese army has about 80,000 troops, with around 5,000 of them deployed in the south. Drone strike hits car in Damascus, Syrian news agency says DAMASCUS, Syria — Syria’s state news agency says a drone strike hit a car in a suburb of the capital, Damascus, killing one person. The agency did not give further details or say who was killed. It said the attack occurred Tuesday on the road leading to the Damascus International Airport south of the city. The area is known to be home to members of Iran-backed militant groups. Israel is believed to have carried out a number of strikes in the area in recent months as it has battled Iran-backed Hezbollah in neighboring Lebanon. Israeli officials rarely acknowledge such strikes. Israel warns the Lebanese state over ceasefire JERUSALEM — Israel’s defense minister warned that if the shaky ceasefire with Hezbollah collapses, Israel will widen its strikes and target the Lebanese state itself. He spoke the day after Israel carried out a wave of airstrikes that killed nearly a dozen people. Those strikes came after the Lebanese militant group fired a volley of projectiles as a warning over what it said were previous Israeli violations. Speaking to troops on the northern border Tuesday, Defense Minister Israel Katz said any violations of the agreement would be met with “a maximum response and zero tolerance.” He said if the war resumes, Israel will widen its strikes beyond the areas where Hezbollah’s activities are concentrated, and “there will no longer be an exemption for the state of Lebanon.” During the 14-month conflict between Israel and Hezbollah, which came to an end last week with a ceasefire brokered by the United States and France, Israel largely refrained from striking critical infrastructure or the Lebanese armed forces, who kept to the sidelines . When Israeli strikes killed or wounded Lebanese soldiers, the Israeli military said it was accidental . The ceasefire agreement that took effect last week gives 60 days for Israel to withdraw its forces from Lebanon and for Hezbollah militants to relocate north of the Litani River. The buffer zone is to be patrolled by Lebanese armed forces and U.N. peacekeepers. Israel has carried out multiple strikes in recent days in response to what it says are violations by Hezbollah. Lebanon’s parliament speaker, Nabih Berri, accused Israel of violating the truce more than 50 times in recent days by launching airstrikes, demolishing homes near the border and violating Lebanon’s airspace. Berri, a Hezbollah ally, had helped mediate the ceasefire. Israeli airstrike in northern West Bank kills two Palestinians JERUSALEM — Palestinian officials say an Israeli airstrike in the northern West Bank has killed two Palestinians. Israel’s military said it struck a militant cell near the town of Al-Aqaba, in the Jordan Valley. It did not immediately give more details. The Palestinian Health Ministry confirmed the two deaths and said a third person was moderately wounded. About 800 Palestinians have been killed by Israeli fire in the West Bank since Hamas’ Oct. 7, 2023 attack out of Gaza ignited the war there. Israel has carried out near-daily military raids in the West Bank that it says are aimed at preventing attacks on Israelis, which have also been on the rise. Israel captured the West Bank, the Gaza Strip and east Jerusalem in the 1967 Mideast war. The Palestinians want all three territories for an independent state. Iran's ambassador to Lebanon reappears after pager attack BEIRUT — Iran’s ambassador to Lebanon made his first public appearance in Beirut since he was wounded in an attack involving exploding pagers in mid-September. Mojtaba Amani, who returned to Lebanon over the weekend after undergoing treatment in Iran, visited on Tuesday the scene south of Beirut where Hezbollah leader Hassan Nasrallah was killed in an Israeli airstrike on Sept. 27. Speaking about the airstrike that destroyed six buildings and killed Nasrallah and others, Amani said Israel should get for its act “the highest medal for sabotage, terrorism, blood and killing civilians.” Amani suffered serious injuries in his face and hands when a pager he was holding exploded in mid-September. The device was one of about 3,000 pagers that exploded simultaneously, killing and wounding many Hezbollah members. A day after the pager attack, a similar attack struck walkie-talkies. In total, the explosions killed at least 37 people and wounded more than 3,000, many of them civilians. Last month, a spokesperson for the office of Israel’s Prime Minister Benjamin Netanyahu said the pager attack was approved by Netanyahu.Netanyahu says he supports proposed ceasefire with Lebanon's Hezbollah JERUSALEM (AP) — Israeli Prime Minister Benjamin Netanyahu says he will recommend his Cabinet adopt a United States-brokered ceasefire agreement with Lebanon’s Hezbollah, as Israeli warplanes struck across Lebanon, killing at least 24 people. The Israeli military also issued a flurry of evacuation warnings on Tuesday — a sign it was aiming to inflict punishment on Hezbollah down to the final moments before any ceasefire takes hold. For the first time in the conflict, Israeli ground troops reached parts of Lebanon’s Litani River, a focal point of the emerging deal. In a televised statement, Netanyahu said he would present the ceasefire to Cabinet ministers later on Tuesday, setting the stage for an end to nearly 14 months of fighting. Trump's threat to impose tariffs could raise prices for consumers, colliding with promise for relief DETROIT (AP) — If Donald Trump makes good on his threat to slap 25% tariffs on everything imported from Mexico and Canada, the price increases that could follow will collide with his campaign promise to give American families a break from inflation. Economists and industry officials say companies would have little choice but to pass along the added costs, dramatically raising prices for food, clothing, automobiles, booze and other goods. The president-elect floated the tariff idea and an additional 10% tax on goods from China, as a way to force the countries to halt the flow of illegal immigrants and drugs into the U.S. But his posts Monday threatening tariffs on his first day in office could be a negotiating ploy to get the countries to change behavior. Mexico suggests it would impose its own tariffs to retaliate against any Trump tariffs MEXICO CITY (AP) — Mexican President Claudia Sheinbaum has suggested Mexico could retaliate with tariffs of its own, after U.S. President-elect Donald Trump threatened to impose 25% tariffs on Mexican goods if the country doesn’t stop the flow of drugs and migrants across the border. Sheinbaum says she is willing to engage in talks on the issues, but said drugs were a U.S. problem. She says "one tariff would be followed by another in response, and so on until we put at risk common businesses,” referring to U.S. automakers that have plants on both sides of the border. Trump won about 2.5M more votes this year than he did in 2020. This is where he did it Republican Donald Trump’s support has grown broadly since he last sought the presidency. In his defeat of Democrat Kamala Harris, Trump won a bigger percentage of the vote in each one of the 50 states, and Washington, D.C., than he did four years ago. According to an Associated Press analysis, he won more actual votes than in 2020 in 40 states. Even with turnout lower, Trump received 2.5 million more votes than he did in 2020. Trump cut into places where Harris needed to overperform to win a close election, especially in swing-state metropolitan areas that have been Democrats' winning electoral strongholds. Now Democrats are weighing how to regain traction ahead of the midterm elections in two years. Biden proposes Medicare and Medicaid cover costly weight-loss drugs for millions of obese Americans WASHINGTON (AP) — Millions of obese Americans would be eligible to have popular weight-loss drugs like Wegovy or Zepbound covered by Medicare or Medicaid under a new rule the Biden administration proposed Tuesday morning. The proposal, which would not be finalized until after President-elect Donald Trump takes office, could cost taxpayers as much as $35 billion over the next decade. It would give millions of people access to weekly injectables that have helped people shed pounds so quickly that some people have labeled them miracle drugs. New rule allows HIV-positive organ transplants People with HIV who need a kidney or liver transplant will be able to receive an organ from a donor with HIV. That's according to a new rule announced Tuesday by U.S. health officials. Previously, such transplants could be done only as part of research studies. The new rule takes effect Wednesday. It's expected to shorten the wait for organs for all, regardless of HIV status, by increasing the pool of available organs. The practice is supported by a decade of research, during which 500 transplants of kidneys and livers from HIV-positive donors have been done in the U.S. Surveillance tech advances by Biden could aid in Trump's promised crackdown on immigration President-elect Donald Trump will return to power next year with a raft of technological tools at his disposal that would help deliver his campaign promise of cracking down on immigration — among them, surveillance and artificial intelligence technology that the Biden administration already uses to help make crucial decisions in tracking, detaining and ultimately deporting immigrants lacking permanent legal status. One algorithm, for example, ranks immigrants with a “Hurricane Score,” ranging from 1-5, to assess whether someone will “abscond” from the agency’s supervision. Ukraine says Russian attack sets a new record for the number of drones used KYIV, Ukraine (AP) — The Ukrainian air force says Russia launched 188 drones against most regions of Ukraine in a nighttime blitz, describing it as a record number of drones deployed in a single attack. It said Tuesday that most of the drones were intercepted, but apartment buildings and critical infrastructure such as the national power grid were damaged. No casualties were immediately reported in the 17 targeted regions. Russia has been hammering civilian areas of Ukraine with increasingly heavy drone, missile and glide bomb attacks since the middle of the year. The Russian Defense Ministry, meanwhile, issued a rare official acknowledgement of its assets being hit on its own soil by U.S.-made longer-range missiles that the U.S. recently authorized Ukraine to use. UK Supreme Court hears landmark legal challenge over how a 'woman' is defined in law LONDON (AP) — The U.K. Supreme Court has begun hearing a legal challenge focusing on the definition of “woman” in a long-running dispute between a women’s right campaign group and the Scottish government. Five judges at Britain’s highest court are considering a case which seeks to clarify whether a trans person with a gender recognition certificate that recognizes them as female can be regarded as a woman under equality law. While the case centers on Scottish law, the women's campaign group bringing the challenge has said its outcome could have U.K.-wide consequences for sex-based rights as well as everyday single-sex services such as toilets and hospital wards. Childhood cancer patients in Lebanon must battle disease while under fire BEIRUT (AP) — Lebanese families with children diagnosed with cancer are now grappling with the hardships of both illness and war. One family now has to drive three hours to reach the center where their 9-year-old gets treatment. It used to take just 90 minutes. Other families have been displaced by an intensified Israeli bombardment that began in late September. The Children’s Cancer Center of Lebanon quickly identified each patient’s location to ensure treatments remained uninterrupted, sometimes facilitating them at hospitals closer to the families’ new locations. Doctors too have struggled during the war.

Department for Infrastructure refuses to respond to questions on city centre congestion